The American diet tends to be low in omega-3 fatty acids, and this may have an impact on acne, according to a review published in “Dermato. Dinner: 5 bites of anything. Lewis provides 3 bites of macaroni and cheese with 2 bites of apple pie as being acceptable choices for his diet plan. A ketonic diet helps your body burn stored fat for energy, instead of glucose. Most low- carb diets are ketonic, also called ketogenic - - the word comes from . The Atkins diet is an excellent example of a ketonic diet plan. A ketonic diet limits carbohydrates, which your body is readily able to convert into glucose. A ketogenic eating plan substitutes protein and fat for carbohydrates in your diet. A ketonic diet shouldn't eliminate all carbs. You'll still need to eat high- fiber vegetables and a limited amount of fruit, but it will restrict starchy vegetables such as potatoes, corn and peas, as well as most grains, some legumes and all refined sugars. Ketosis, a condition caused by incomplete fat breakdown, is a concern with ketogenic diets. Ketosis can cause weakness, nausea, dehydration, dizziness and irritability. You'll know if you're in ketosis by checking your urine; special test strips can measure the amount of ketones your body is excreting. MyFoodMyHealth: Online tools to manage a diet for High Blood Pressure: meal planner, 100's of recipes, printable shopping lists and more. Today I want to show a pretty entertaining diet plan that I found last night. Last night, as my girlfriend was digging around her kitchen cabinets searching for a. Includes: free printable meal plan, how to use the plan, benefits of low-calorie low-carb eating, following the plan, and weight control. Arnold Schwarzenegger Workout A – Performed on Monday, Wednesday and Friday. Bench press – 5 sets, 6-10 reps; Flat bench flies – 5 sets, 6-10 reps. What is the best thyroid diet? Hedberg give you the best information on exactly how to eat for optimal thyroid function and Hashimoto's disease. The WholeApproach® Candida Diet provides nutritional support to increase the effectiveness of the WholeApproach® Program of natural anti-fungal products. Only carbohydrates raise your blood sugar and cause your body to release insulin. Fat, protein and fiber slow the absorption of sugar into your bloodstream and help stabilize glucose levels. One theory behind ketogenic diets and weight loss is that having less insulin helps eliminate food cravings. Because your blood sugar is stable, episodes of hypoglycemia, low blood sugar, don't trigger attacks of sudden hunger and subsequent binge eating. If you consume fewer calories, you'll lose weight. Ketonic diets appeal to a lot of people because they generally don't involve calorie counting or portion control. You can eat as much as you like of animal protein and fats, while restricting sweets, breads, pastas, most fruits and starchy vegetables. For example, the strictest phase of the Atkins diet allows for up to 2. So if a vegetable has 3 grams of carbs and 2 grams of fiber, it has 1 gram of net carb. This should allow you enough vegetables to meet your daily nutritional requirement, although you still may need to take a vitamin supplement. Ketonic diets may be safe in the short- term, but more research is needed about long- term health effects of restricting carbohydrates. Side- effects of ketonic diets can include dehydration, dizziness, irritability and bad breath. Although ketones are mainly excreted in your urine, excess ketones also leave your body in your perspiration and breath - - and ketones don't smell good. A high protein diet can be very high in saturated fat and cholesterol, which may raise your risk of heart disease. What You Eat, How It Works. The ketogenic diet is one of the oldest treatments for epilepsy. The Down Low on Low-Carb Diets. How to avoid the pitfalls and side effects of a low-carb weight loss plan. It is intended to maintain the starvation or fastingmetabolism over a long period of time. When the body is in a fasting state, it creates ketones, a by- product of fat- burning metabolism. It has long been recognized that seizures often lessen or disappear during periods of fasting in some individuals with epilepsy. The diet is very high in fat and low in carbohydrates. When fat is the primary source of calories, ketones are formed. The diet must be followed very strictly and requires a significant commitment to work effectively. Children on the diet often will not gain weight or grow much during the time the diet is in use. After that, however, growth is expected and should be carefully monitored. The diet has been used mostly in children with difficult- to- control, generalized epilepsies - - such as those with the Lennox- Gastaut syndrome. Lennox- Gastaut is a generalized epilepsy which is characterized by drop attacks or tonic- clonic attacks (with violent, rhythmic convulsions) and often occurs in children with other neurological conditions, such as paralysis and mental retardation. It's often very resistant to treatment. In this group of individuals, the diet can be as successful as medications. Thus, it is most often recommended for children ages 2 through 1. Recent studies have shown that the diet may also be effective in those with partial seizures. The diet is typically started with a period of fasting that lasts until the body produces a moderate to large amount of ketones. This initiation period usually takes place in the hospital, so that the individual can be monitored for potential side effects such as vomiting, low blood sugar, dehydration, and seizures. Medications may also be adjusted during this period to prevent sedation (the tranquilizing effect of medications), another common side effect. A two- month trial period is suggested for deciding whether the diet is effective. If it is, it is typically continued for two years. During this time, individuals are often able to lessen the amount of medication they take for seizures. Many children seem happier and more alert on the diet, even before medication is significantly lessened. People on a ketogenic diet should be monitored by a dietitian, nurse and doctor - - particularly a neurologist - - familiar with its use. Specialized epilepsy clinics are available to monitor a person on this diet. Web. MD Medical Reference. Reviewed by Neil Lava, MD on July 2. Sources. SOURCE: University of Medicine & Dentistry of New Jersey - The University Comprehensive Epilepsy Center..
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The Athlete Lorazepam (Ativan) Ativan is in the class of drugs known as benzodiazepines. These are psychotropic drugs with potent hypnotic and sedative action; used. Best Natural Antidepressants . Oz Show. While everyone experiences “the blues” from time to time, depression is a kind of low mood that can affect a person’s ability to effectively live and enjoy life. Depression impacts about 1. The World Health Organization predicts depression to become the second most burdensome disease by 2. My Depression Drug Is Not Working and It’s Making Me Fat.”If you feel your medication is not really helping, and is causing unwanted problems like weight gain and low sex drive, you are not alone. As one of the most well prescribed types of drug of all time, over 1. Journal of the American Medical Association revealed antidepressants to be no more effective than placebos (sugar pills) in most cases of depression. Anti- depressants are shown to be helpful in the minority of very severely depressed cases, and should be used when needed for these cases. Studies also show that antidepressants can cause a laundry list of side effects, including sexual side effects, fertility problems, increased weight gain and diabetes risk, blood- pressure problems, increased heart attack risk, heart defects in unborn children – even increased desire to commit suicide. The Naturopathic Advantage for Depression. The reason why antidepressants do not work in most cases of depression is because these drugs target only one aspect of this complex condition: neurotransmitters, the brain's. Drug Options for the Treatment of Depression. Drowsiness, blurred vision, lightheadedness, strange dreams, constipation, fever/chills, headache, increased or decreased appetite, tremor, dry mouth, nausea. Remeron can be sedating and cause weight gain. Cymbalta may increase sweating and blood pressure and also cause fatigue and reduced energy. 5-HTP supplement depression side effects dosage, sleep benefit, for stress, appetite suppression, weight loss dosage. What is the Best Anti-Anxiety Medication? Those that live with anxiety every day know how important it is to get relief. Anxiety is a life altering condition, and one. I have been treated for depression for over 20yrs and now have severe major depression for last 6 months. I take 150 mg Effexor XR and it doesn't seem to be working. While everyone experiences “the blues” from time to time, depression is a kind of low mood that can affect a person’s ability to effectively live and enjoy life. Why should I sign up for WebMD? With a WebMD Account you can: Track your way to weight loss success; Manage your family's vaccinations; Join the conversation. Learn about the different types of pain medication used for pain relief. Learn about over the counter and prescription pain medication. Best Treatments for Depression Therapy can work as well or better than antidepressants for major depression, so consider it first. We love to share wholesome and delicious recipes, perfect for home cooked family meals. More About Simply Recipes. Here you have a delicious and very easy recipe for this summer! Greek Style Salad, it's really simple to make, so full of flavor and beautiful. Using phyllo dough is easy and here are five fabulous phyllo appetizer recipes to prove it. Mediterranean Diet ranked #2 in Best Diets Overall. 38 diets were evaluated with input from a panel of health experts. 1 slice whole-wheat bread spread with 2 Tbsp. Looking for the best Appetizer recipes? Get recipes like Scallion Pancakes, Old Bay Chicken Wings and Sour Cream and Bacon Deviled Eggs from Simply Recipes.Super-Fast and Easy Appetizer Recipes. We've got your recipes for healthy party food. Diet.com provides diet, nutrition and fitness solutions. Meet your weight loss goals today! Your daily values may be higher or lower depending on your calorie needs. More Diet Meal Plans and Diet Recipes. 7-Day Weight-Loss Diet Meal Plan; EatingWell 7-Day Meal Plan Help; EatingWell's 500-Calorie Dinners; Weight-Loss Diet Meal Plan. Personal training Best Gym Membership Deals Around the Country Get fit and save money with these discounted exercise plans. The Testosterone Dilemma - Men's Journal. If you've ever wondered why modern American life seems bent on making you less of a man, a new study from Northwestern University may have your answer. Raising children decreases men's testosterone, reports the study. Its authors, anthropologists at Northwestern, suggest that this decline in testosterone helps facilitate men's . But emerging evidence suggests that men have less testosterone today than their fathers did, most likely owing to increasing rates of obesity and possible exposure to environmental toxins.
Add this to the results of the Northwestern study, and they add up to a grim prognosis for middle- aged men helping their wives raise children in a polluted world. It also adds up to a vast target market for the obvious cure: testosterone replacement therapy, or TRT. The sales pitch for TRT reads like a wish list for every man on Earth: build muscle, trim fat, improve mood, recharge energy, crank up sex drive. No wonder prescriptions for the therapy have jumped 5. MSN Health and Fitness has fitness, nutrition and medical information for men and women that will help you get active, eat right and improve your overall wellbeing. But while more men are trying TRT, a fierce debate rages among doctors about the safety and ethics of prescribing it to anyone without a defined deficiency. The therapy has serious side effects, and the long- term risks aren't known – and may not be for decades. Approximately 3. 0 percent of men ages 4. L (nanograms per deciliter), with symptoms that include muscle atrophy, weight gain, exhaustion, depression, bad sleep, disinterest in sex, and/or erectile dysfunction. Before prescribing TRT for hypogonadism, a responsible doctor will recommend lifestyle changes to raise testosterone levels, including weight loss, exercise, and better sleep, says Dr. Harry Fisch, a professor of urology at Manhattan's Weill Cornell Medical College. Only when these modifications fail to cure a patient do TRT's benefits outweigh its risks, he adds. The controversy surrounding TRT starts with doctors like Harvard Medical School's Dr. Abraham Morgentaler, who believes that more men suffer from hypogonadism than meet the condition's standards, and in 'Testosterone for Life,' he writes that fading testosterone should be considered a treatable part of the aging process. We treat all of these to improve the quality of life or to increase longevity. Should we withhold offering prescription glasses to older men and women because poor vision is common with advancing years? Jeffry Life, the buff 7. Las Vegas–based Cenegenics Medical Institute precisely because his tremendous physique demonstrates how synthetic testosterone can help men defy expectations of frailty and physical decline. Elizabeth Yurth, catering to Colorado's sports- enthusiast crowd at the Boulder Longevity Institute, says testosterone is . Testosterone can help change all that. But it could also be argued that Yurth and Life are simply bringing men back up to the testosterone levels enjoyed by their forefathers. Population- wide, testosterone levels have dropped markedly in the past 2. Obesity plays a role, since body fat helps turn testosterone into estrogen. But even when the research is corrected for weight and smoking, it suggests that other factors may be at play – environmental toxins, perhaps. A study from the University of California, for example, found that atrazine, a common pesticide, is so high in estrogen that it can transform an adult male frog into a fully reproducing female. Some doctors, like Life, believe that medicine's current standard of . Life likes to boost patients' testosterone to 8. L, pointing to studies that show that men with testosterone levels in the upper 2. I'm going to the gym, but I dread it, and I'm losing muscle mass and strength, even though I'm working out, and I'm getting belly fat.' So they give you a blood test, and your hormone levels come back at 3. You're told you're normal, so you walk out thinking, 'I got normal testosterone. What's up?' What they won't tell you is that you're really a D student. For one, evidence suggests that high testosterone may accelerate prostate cancer. And the Northwestern study makes the point that lower testosterone levels in fathers may be an evolutionary occurrence, helping men become more sensitive and nurturing and, thereby, better dads. Yet Fisch and others counter that fathers' declining testosterone levels aren't evolutionary but a result of the demands of child raising. Natan Bar- Chama of New York City's Mount Sinai Medical Center, question if more testosterone can also help other symptoms like depression, fatigue, and libido. But are there also wellness centers giving people sesame oil and telling them it'll cure all diseases? While large studies have shown lower mortality at higher testosterone levels, more recent research has found just the opposite, or that higher testosterone correlates with higher cardiac risk. One TRT study even had to be halted last year because of an uptick in cardiac events among subjects. TRT has other side effects, too, including shrunken testicles, hair loss, acne, breast enlargement, and sterility. The therapy can also raise hematocrit levels (red blood cell concentration), which in turn can help improve athletic performance. But if your hematocrit level gets too high, the blood can become so viscous that it increases the risk of stroke and heart attack. And what many patients don't realize, says Bar- Chama, is that testosterone is a . Your brain sees the level is normal and shuts down. Of course, there could also be dangers to TRT that doctors don't entirely understand yet. When hormone replacement therapy was first used with women, it was considered to be very safe.. But it became clear that HRT not only increases the risk of certain cancers, it is not beneficial to the heart. Robert Mordkin, a urologist in Arlington, Virginia. Furthermore, Mordkin adds, . And for those guys whose blood levels come under definitions of low testosterone, it's probably reasonable to try the therapy for a while. But that's very different from saying testosterone is the fountain of youth. From the YOU: On a Diet book, Drs. Oz and Roizen are sharing the 14-Day YOU Diet. Click here to purchase your copy. Get started on changing your body from the inside. Detailed diet plan for day 2 of the GM Diet also knows as the general motors diet. How to plant more "good carbs" into your diet by adding healthy fiber. The Keto Beginning Guide and Meal Plan. All forms of carbohydrate – fruits, vegetables, grains, and starches, are broken down into glucose by your body, increasing your blood sugar. Your body considers raised blood sugar as being toxic, so it releases insulin (a storage hormone) to push the glucose into your cells. Once this occurs, your blood sugar decreases, making you hungry again. This vicious cycle of blood sugar highs and lows is why you experience endless hunger and cravings. The release of insulin halts your body’s ability to release fat and toxins. If you’re eating carbohydrate- based foods every 2- 3 hours, your body is never fully able to exercise its ability to rid itself of excess. And, if more carbohydrates are consumed than what your body needs, it will be converted into triglycerides and stored in your blood, leading to weight gain and unbalanced cholesterol. But, when we lower our intake of carbohydrates, increase our consumption of glorious fats and moderate our protein intake, our blood sugar and insulin levels are reduced, levels of HDL cholesterol increase, and the visceral fats around your vital organs are “eaten up”. This is nutritional ketosis. In nutritional ketosis, your body becomes a fat- burning machine, effectively breaking down fatty acids into ketone bodies that are used, even by the brain, as fuel. Studies show that nutritional ketosis has the potential of alleviating food cravings, blood sugar irregularities, mind fog, excess body weight, abnormal cell growth, psychological imbalances, infertility and more. In nutritional ketosis, we’re tripping the metabolic switch, leading to so much more than just weight loss. Achieve the state of health you’ve been searching for. 30 Day Diet Creative BioscienceGet started today for your dream abs in only 1 month! Build a stronger marriage one day at time as you take Nancy's 30-Day Husband Encouragement Challenge. I used this 30-day reset autoimmune diet plan to help manage my Hashimotos Thyroiditis and get my autoimmune disease into remission. Day Keto Diet Plan. THE 30-DAY GREEN SMOOTHIE CHALLENGE Affordable 21 day personalized Keto diet plan for men & women. Weight-loss like you have never experienced before! Let's get started with a Ketogenic Diet! Diet Plan To Lose Weight Fast - The 3 Week Diet. Instead, it discusses the science behind how we gain and lose weight as well as what absolutely needs to be done to attack that stubborn body fat that, until now, has been so challenging to get rid of. In addition to this, The Introduction Manual will discuss the specific recommended supplements weight loss for this diet to be ultra- successful and the science behind those supplements, and how they help you lose fat, increase metabolism and become much more healthy and energetic. DIET MANUALThe Diet Manual is where the . From my experience a lot of people hesitate to even try and lose weight because they don. They know that they should go on a diet and. Podcast: Play in new window . Cheating on the hCG Diet: What To Do When You. It's about time I compiled a comprehensive guide to my system, so here it is. Intermittent fasting and Leangains How does Leangains differentiate itself from some. In addition to this, you'll discover the exact foods you must eat to maximize your body. Also included in The Diet Manual is my ultimate, super- simple plan for keeping the weight you. This allows you to live a . If you have already been diagnosed with a mental health problem, eating well can even help to manage your symptoms and regain control of your life. While The Diet Manual alone will produce truly amazing amounts of fat loss, The Workout Manual can help you to nearly double your results. This was specifically designed for those who don. The simple fact is, exercising for fat- burning is not about spending hours in the gym everyday. This is because fat loss is dependent on intensity. The key to smashing fat- loss plateaus lies in short and intense, full body exercises that get every muscle in your body metabolically active. When you add a quality workout program with The 3 Week Diet, you truly have the ultimate . The Workout Manual also includes my ultimate Midsection Miracle Workout, which contains the only two abs exercises you will ever need if you desire a set of 6- pack abs. Many have said that this exercise alone is worth much more than the price of my system! Every great success starts with a decision to change your mindset. This manual will give you the techniques to focus on your goals and remain motivated throughout The 3 Week Diet and beyond into your everyday life. The Rapid Fat Loss Handbook : Bodyrecomposition. The Rapid Fat Loss Handbook. A Scientific Approach to Crash Dieting. Related Articles: GM Diet Day 3 Day 3, nearly half way through the GM Diet. Things should only get easier now. GM Diet Day 2 Like the first day of. Optifast is a diet program I will surely never forget. We at DietSpotlight decided to create a comprehensive review, scrutinizing the ingredients, side effects. How to Lose 5 Kilograms in One Week. Losing any amount of weight in one week may seem impossible, but it is actually quite doable. This wikiHow will show you how to. Second Edition. Package Includes: The Rapid Fat Loss Handbook: 9. Home Exercise Handbook (PDF)Calculator Instructions (PDF)Show me my purchase options. About the Book. The Rapid Fat Loss Handbook offers a scientifically based approach to quick weight and fat loss. Recognizing that people need or simply want to lose weight and fat rapidly, I set out to develop the safest, most effective way of accomplishing that goal. I based the program around the idea of creating a diet that would provide the fewest calories possible while still providing all of the essential nutrients required by the body: protein, essential fatty acids, vitamins and minerals. This provides simply the safest and sanest way to lose fat quickly without sacrificing health (or muscle mass). Every aspect about how to set up the diet is laid out in a step by step form and the diet is based around whole foods that can be found at any market. With purchase of the book, you’ll also receive instructions for how to access an online calculator that will set up the diet and provide food recommendations. As well, the diet also incorporates concepts I’ve discussed on this site: free meals, refeeds and full diet breaks to help with both adherence and the body’s tendency to fight back when dieting. Guidelines are provided for when to take them, how to use them, etc. In addition, guidelines for moving back to maintenance, as well as for using the program to transition into a more moderate fat loss diet are provided in detail. Specific training guidelines are also provided in order to provide the best results with the least time investment. Massive amounts of exercise aren’t needed; quite in fact, too much exercise while on the rapid fat loss program can hinder results. Quite in fact, for the extremely overweight, no exercise is actually required to reap the benefits of the program. The book provides specific recommendations (for everyone from beginners to advanced trainees) for both resistance training and aerobic activity in terms of how often and how much will provide the best results. As well, realizing that most people can’t or won’t join a gym, I developed a small home- exercise handbook outlining a basic routine that can be followed with no or minimal equipment. This is included with your purchase as a digital download. Table of Contents. Introduction. Chapter 1: Just how quickly? Chapter 2: When is a crash diet appropriate? Chapter 3: Basic nutrition overview. The Rapid Fat Loss Handbook offers a scientifically based approach to quick weight and fat loss. Recognizing that people need or simply want to lose weight and fat.Chapter 4: Nutrient Metabolism Overview. Chapter 5: An Overview of the Diet. Chapter 6: Estimating body fat percentage. Chapter 7: Exercise. Chapter 8: Setting up the diet. Chapter 9: Metabolic slowdown and what to do about it. Chapter 1. 0: Free meals, refeeds and diet breaks. Chapter 1. 1: Ending the Diet – Introduction. Chapter 1. 2: Moving to Maintenance: Non- counting Method Part 1. Chapter 1. 3: Moving to Maintenance: Non- counting Method Part 2. Chapter 1. 4: Moving to Maintenance: Calculation method. Chapter 1. 5: Back To Dieting. Appendix 1: BMI and Body fat charts. Show me my purchase options Excerpt. The following is an excerpt from Chapter 1: Just How Quickly? What can you expect? On average, caloric intakes on this diet will come out to between 4. For those of you familiar with ketogenic (low- carbohydrate, high- fat) diets, a PSMF is essentially a ketogenic diet without the dietary fat. Obviously, this will represent a fairly large caloric deficit; how large depending on your starting body weight and activity levels. So with all of that in mind, you may still be wondering what you can expect in terms of true fat loss per week. A lot of it, actually, will depend on where you’re starting out body weight wise (activity also factors in), as that determines your maintenance caloric level. A 1. 65- pound male with normal activity patterns may have a maintenance requirement of about 2. At 8. 00 calories per day on this diet, that’s almost a 2. Assuming all of the true (non- water) weight lost was fat (it won’t be), that should be an 8- pound fat loss in 2 weeks (2. The true fat loss will be lower because of various inefficiencies and the slowdown of metabolic rate (which can start after only 3- 4 days of severe caloric restriction). A larger individual, say 2. At 8. 00 cal per day on this diet, that’s a 3,0. Over 2 weeks, that’s a 4. That’s on top of the 1. Females or lighter individuals with their generally lower maintenance caloric requirements will lose less. True fat losses of 1/2 pound per day or slightly less may be all that they get: that still amounts to a considerable fat loss (6- 7 pounds true fat loss over 2 weeks) along with the extra water weight loss. Show me my purchase options. Customer Feedback. If a picture is worth a thousand words, then Jay’s before and after pictures here should tell you everything you need to know.“I purchased Lyle Mc. Donald’s Rapid Fat Loss Handbook in hopes of losing a few pounds quickly. The diet did not disappoint, in just 1. I lost 7. 8 lbs, going from 1. Mary Ellen, South Carolina“I’ve been lifting weights for 3. I am well aware of the nutritional needs of humans, and nearly every theory of dieting ever advanced. I’ve done most every type of diet. I have never had such an easy time losing so much fat with so little muscle loss in such a short period of time (5. I have with Lyle’s PSMF. In addition, and more importantly, after just one month on the diet, markers of health. Truly amazing.”– David W Cohen, NVClick to Enlarge“I put a world class BJJ (brown belt) athlete on a modified RFL diet about 3 weeks before the Pan American games 3. March in Los Angeles. I synopsized the diet for him so it was easy- to- read, is all. He called in a panic 3 weeks out because the Pan American games were approaching and he was still 4# over weight and hadn’t been able to lose it on his own. The guy was very lean already so it’s a tricky situation but he pulled it off. March 3. 0th he won the gold medal in his weight class. He weighed in 1# below weight, he looked and felt great and fought like a freak. Back to the kid, now his own BJJ coach (who also competes and also won gold 3. March in the Masters black belt division) sent word that in observing how well Zak performed on the diet and going on to win the Pan Ams that he wants to do it as well to drop a little weight for the upcoming BJJ World’s tournament the first week of June. Attached is a photo when he won the finals. You can see the shape he’s in. He’s just beaten the guy who’s been an arch rival for years. Very tough match.”After 7 weeks on the Rapid Fat Loss plan“I am amazed at how this program worked for me. Knowing that a refeed/free meal was right around the corner gave me the willpower to be STRICT with the low calorie days. Unlike most programs that tell you how to lose weight, RFH also devotes several chapters about how to maintain your weight. The book is very concise and I couldn’t be happier about my results!”J. Tsoi – Houston, Tx“Your Rapid Fat Loss e- book really put me on the right course. I have gone from 3. Your no nonsense plan is extremely easy to follow and the best part is. Thank you for this fantastic information that WILL help me achieve the body of my dreams.”Forever Grateful,– Bill Evans in Seaford Delaware“Looking for a fast and easy way to lose weight? There are plenty of so- called crash diets, but only one diet rooted in science and physiology allows you to do so safely without losing precious muscle mass and slowing down your metabolism – the Protein Sparing Modified Fast (PSMF). In The Rapid Fat Loss Handbook, Lyle Mc. Donald has distilled this method with decades of research behind it into practical guidelines, with easy- to- understand categories depending on your starting point in bodyfat, weight and fitness level. You will learn how to set up the diet, implement free meals and refeeds to not only maintain metabolism but also make the diet easier to follow. Follow the guidelines in this book, where Lyle even provides you with free online resources on how to set up meal plans and an exercise program, and you will lose a lot of fat in a very short time while preserving muscle mass and strength.”Borge (aka Blade) – Norway. Myo. Revolution“Thank you so much for writing your book. I’ve done low carb dieting and intense exercise in the past and lost 4. Like many others I took things to the extreme and could not maintain. I completed banned all carbs, even some good ones. I started low carbing again about a week before I ordered your book online to lose excess water by banning carbs and I didn’t think to incorporate some really healthy high fiber carbs in portion controlled amounts into my prior weight loss as I do with my two free meals. Thanks to your advice I have successfully lost 2. My water retention, high blood pressure is down and my glucose is in balance. I feel great, I’m not hungry, the fish oil is amazing and this really doesn’t feel like a diet. The two regular meals on Sat and Tuesday with exercise a few times a week really help keep me on track. I make sensible choices and I don’t feel deprived. I feel this is a lifestyle I can enjoy permanently.”D. Mc. Gruder – Florida“Muata over at mrlowbodyfat. I send you an email. I found your RFL diet on his blog, and between his inspirational posts and your easy to follow diet, I’ve just completed an 8 week run of RFL starting as a 2. I’m going to take a 2 week break, which actually falls at a great time with Memorial day, my birthday, and my daughter’s birthday, and resume as a cat 2 dieter. I just want to say thanks for developing this diet, and staying active with it with the blog and following the forums. Most diet author types might write the book, but then there is no more contact. You, on the other hand, are available and helpful. Please note that all three products including two digital files: The Home Exercise Handbook and a file titled Calculator. Optifast Review - Better Diet Plan Than the Competition? Optifast is a diet program I will surely never forget. We at Diet. Spotlight decided to create a comprehensive review, scrutinizing the ingredients, side effects, customer- service quality and clinical studies. Moreover, we read dozens of user comments that are posted online. Lastly, we compacted everything we found to give you the important facts you need. Optifast Readers: Click here to find out why we're giving away samples of our product, Leptigen. What is Optifast? To start, Optifast is boasted as . This program involves the following; meal replacement diet, medical supervision, lifestyle education, counseling and ongoing personalized support. The products from Optifast include shakes, soups, protein drinks, nutrition bars and vitamin and mineral supplements, which are made by Nestle. Optifast has been around since at least 2. There are clinic locations all over the United States and Canada. Also, a helpful FAQ section is provided on the website, but read on. In fact, this weight- loss program may end up costing you well over $1,0. This is especially true if you stick with it for the full 2. For the privilege of just being there! You also have to pay in advance. This is never a good sign. After a couple of days of trying to get them down, I stopped using them completely. I thought I could hold fast to no food, but two weeks I have to admit I was tweaking.”According to our research, if there is some certain aspect of a diet program that is very annoying or concerning (high cost, negative dieter reviews, a difficult exercise) the likelihood of prolonged weight- loss success is minimal. Unfortunately Optifast does not really elaborate on clinical studies on their website. Even though Optifast is regulated by medical professionals, we feel that the negative dieter reviews and very high cost are major drawbacks. Well, we like Optifast. On the other hand, we have some concerns about this diet program because it. Also, we have some reservations about the numerous negative dieter reviews posted online. This product contains four unique ingredients, which have been shown, via clinical testing, to possibly help speed up fat loss and boost metabolism. It’s also amazing that user reviews posted online reveal people are seeing solid results. Also, the makers of Leptigen are so confident in the formula, they. The Optifast meal replacement products are produced by the famous dessert giant Nestl! The Optifast meal replacement products consist of Ready to Drink Shakes, Powders, Soups, Nutrition Bars, High Protein Drinks, and a Optifast Vitamin and Mineral Supplements. There will also be medical monitoring of your progress, and you will be given a personalized activity plan. You will also be able to partake in discussion groups and have the opportunity to have one- on- one counseling with a registered dietician, lifestyle counselor, or a physician. There is an official Optifast website, but it seems that in order to access the weight loss program you will have to make an appointment at an Optifast Clinic. The website does not give any details of the price of the program, nor the price of the meal replacement clinics. Advantages of Optifast. There is an official website for Optifast. The program includes medical monitoring. The website is sophisticated and easy to navigate. Disadvantages of Optifast. The website does not give details of the cost of the weight loss program. You cannot order the meal replacements on line. You can only undertake the Optifast weight loss program in conjunction with an Optifast Clinic. Having to stick to a pre- prepared diet of Optifast products could become difficult. Though few details are given, it sounds like frequent clinic visits could become time consuming. Conclusion. The Optifast weight loss program does seem to be one of the more serious weight loss program on the market. If what the official website says is correct, the program involves careful medical monitoring and emotional support, as well as a strictly controlled diet. The website does not give any details of the cost of the program, so we do not know if it is easily affordable or what expenses are involved in subscribing to the program. Considering all of the attention users receive from trained professionals, we would imagine it. Additionally, the program does not allow for much freedom in a user. While all of this attention could be beneficial to obese users who need to lose weight badly, those looking to drop a few pounds for aesthetic reasons may want to find something simpler and cheaper. Optifast Questions & Answers: We boiled down hundreds of user comments about Optifast into this helpful FAQ. What are the side effects of Optifast? Optifast side effects may include hunger and fatigue. However, there are no studies available on the official website proving you will lose weight using this program. How much does a bottle of Optifast cost? The cost of a bottle of Optifast varies, considering this is weight- management program. If you take into account meals and visits to the clinic, could easily exceed $1. How do you take Optifast? How you take Optifast products based on your individualized program. Can I take Optifast if I have a health condition? Women who are pregnant or nursing, those with health conditions, anyone taking prescription medications or people under 1. Opti. What do users like about Optifast? Some users liked that they saw results while following the Optifast program. What do users NOT like about Optifast? Many users complained about the high price of Optifast. Who makes Optifast? Nestl? You can contact the Optifast customer service department by calling 1- 8. Nestl. Fremont, MI 4. Can I contact Optifast through social media? Yes, you can contact Optifast through Facebook and Twitter. Is Optifast covered by insurance? This depends on the insurance company you use and the level of coverage you have. Contact your provider prior to beginning the program to find out what, If anything, they cover. Can I eat food while on Optifast? Opti is a three phase program. During the first 1. During the transition program, you move to eating regular food you make yourself. Is Optifast right for me? Optifast is best for patients with a BMI of over 3. It is recommended only as part of a comprehensive treatment program. However, our readers have been going crazy over the past few months taking advantage of Leptigen’s Special Trial Offer. Click above to learn more. References. 1. Centers for Disease Control and Prevention. After analyzing thousands of comments and reviews, these are the tips that we think will help you learn the most about this program. That way your expectations won. You will go to the doctor. There is a definite time commitment. Nothing made the mixes taste good. But it CAN be done on a budget if you are careful. I felt like I was going crazy because of the reduced calories and not being able to eat anything. But once you see results it becomes easier. I had to take a break after seven weeks because I couldn. Data regarding these findings in human participants is less clear. There is information and data on the metabolic and endocrine actions of dietary fructose that indicate elevated consumption of fructose can be destructive in terms of body weight and adiposity as well as the metabolic indexes that come with insulin resistance syndrome. There needs to be more research in order to fully comprehend the metabolic effects of dietary fructose in humans. Triglyceride (0. 6 m mean difference, P=0. P=0. 0. 2) concentrates were raised more in the high carbohydrate groups, while glucose (0. P=0. 0. 2) was higher in the high protein group. Alterations to total cholesterol, high- density lipoprotein- cholesterol, low- density lipoprotein- cholesterol, insulin, Hb. A1c, HOMAir index, adiponectin and leptin concentrations had not changed regarding the diets. It was concluded that low- fat, high- casein or whey protein diets are better for weight control when compared to a low- fat, high carbohydrate diet and do not negatively impact metabolic and cardiovascular risks in moderately obese patients. There were some endocrine- related functions differing between the rats who were administered the proteins. It was found that soy protein isolate had sped up puberty in female rats (p < . The meta- analysis of the results had indicated that gender- specific alterations in development and specific endocrine reactions in the rats that were fed diets containing a single protein source like those used in infant formula. It is unknown whether there would be similar effects in humans, but is thought to be unlikely as most infants do not ingest such diets throughout their lives as the ones given to the rats. None of these effects have been reported within the millions of American infants who were fed instant formula with the same proteins. It had been concluded that the long- term health benefits (reduced breast cancer incidence) of soy protein isolate and whey protein are very likely to be positive. You visit a clinic in your area to start the program. There are meal replacements, soups, bars and supplements. It appears that the shakes are the biggest product. Optifast Ingredients and Supplement Facts. Serving Size: Varies depending on product. Serving Per Container: Varies depending on product Amount per Serving% DVNonfat Dry Milk**Fructose**Calcium Caseinate**Canola Oil**Other Ingredients: Salt, potassium phosphate, magnesium oxide, mono- and diglycerides, choline bitartrate, potassium chloride, ascorbic acid, natural and artificial flavor, alpha tocopheryl acetate, ferrous sulfate, zinc sulfate, vitamin A palmitate, niacinamide, copper gluconate, calcium pantothenate, manganese sulfate, vitamin D3, color (beta carotene, turmeric oleoresin), pyridoxine hydrochloride, thiamine hydrochloride, riboflavin, chromium chloride, folic acid, biotin, potassium iodide, sodium molybdate, sodium selenite, vitamin K1, vitamin B1. How Many Calories Should I Burn a Day to Lose Weight? From my experience a lot of people hesitate to even try and lose weight because they don. They know that they should go on a diet and exercise regime but the lack of measurable goals creates uncertainty and this leads to failure before to even begin! To bypass this problem and have clear goals on what you want to achieve, you can start your weight loss process by doing some simple calorie calculations. By calculating how many calories you should be eating per day and how many calories you should be burning per day, you can have a better picture about your daily calorie needs and a rough estimate as to when you will be able to reach your ideal weight. Before getting into the mathematical part let me explain some basic weight loss concepts that will help you understand what these numbers mean. You do not have to keep a pen and paper because our daily calorie calculator will do the hard part. When do you lose weight? There are many factors that affect how much weight you can lose (and when) but in its simplest form weight loss will occur when the calories you burn are more than the calories you consume. Food and drinks (think diet) are the only sources for calories you consume while exercise, physical activity and other body factors affect the rate you burn calories. So, if you manage to control these 2 sources and create a calorie deficit you will eventually start losing weight. How many calories are in a pound? Let. In essence this figure gives you the number of calories your body needs on a daily basis in order to function properly. Note: This is not how many calories you consume per day but how many calories your body needs to function. BMR and Daily Calorie Calculator. You can use our BMR CALCULATOR above to find out your basic metabolic rate which is based on your weight, age, height and daily activity. We will use BMR to calculate how many calories you should be eating per day and then demonstrate with an example how many calories you should burn per day if you want to lose weight in a specified amount of time. Daily calorie needs to maintain current weight = BMR x Activity Factor. Note: You do not have to take a calculator to make the equation; you can use our daily calorie calculator above. Daily Activity. Activity Factor. Sedentary (little or no exercise)1. Lightly Active (light exercise, doing sports 1- 3 days per week)1. Moderately Active (sports/exercise 3- 5 days per week)1. Very Active (intense sports 6 or 7 days per week)1. Extra Active (sports and exercise, physical job or hard training)1. For example, if your BMR is 1. If you want to lose weight you should be consuming less than 2. How many calories to eat if you want to lose weight? Before getting into a real example of how to calculate the calories you should be eating per day for weight loss let me say that this is only an estimate and it is not guaranteed that by following this number you will lose or gain weight. There are many other factors involved in losing weight and the number of calories you consume is just one of the elements and since it is easy to calculate you can use it as your starting point. Let. Doing some basic calculations you can find out that 1. So in theory, if you manage to save 3. Step 4: Subtract the number of calories you need to save per day (Step 3 above) from your daily calorie needs (step 1 above)Daily Calorie needs . This is the number of calories you need to eat per day if you want to lose 5lb in 2 months! How many calories to burn per day if you want to lose weight? Since you know the number of calories you should be eating per day, you can use a calorie counter to calculate the amount of calories you actually eat (or drink) on a daily basis and find out the amount of calories you need to burn via exercise if you want to lose weight. Hint: You can use our Free Calorie Counter to keep count of your meals and activities. For example, if you are consuming. Especially at the beginning you will lose water weight and in some cases you may also lose muscle. So the results in the first few weeks may be misleading. When you make sudden or drastic changes to your diet the body will try to adapt by lowering the metabolic rate. In other words it enters a protective mode by reducing the number of calories it needs per day. As a result weight loss may slow down, here is how to lose weight and keep it off. The absolute minimum amount of calories you can consume per day is 1. It is not recommended to go beyond this number for any reason. The recommended weight to lose per week is between 1 . Anything above that can have other implications to your health and normal body functioning. Do not forget that drinks also carry calories so make sure that you include drinks in your daily calorie calculations. You can read our article on the 5 best healthy weight loss drinks that work to find out which drinks are . This means that once you calculate your daily calorie needs you can go above and below this range on different days of the week. If for example you daily kcal needs are 1. Monday and Wednesday and below this number the rest days of the week but try to avoid exaggerations. You can also read about carb cycling to access if this is something you want to try for your diet. Make sure that you give correct measurements for your weight and height when calculating your BMR. Do not lie about your activity level but try to be as accurate as possible. Do not decrease your daily calorie intake by more than 5. Better expand the time period. Reducing your intake by 5. Always consult your doctor or dietician before making any changes to your diet or exercise routine. As explained above you can use these calculations to give you an idea where you stand and how much effort you need to make until you meet your goals and target weight. Weight loss depends on a lot more factors and calculating the calories you need per day is just your starting point. Patent US2. 00. 40. Novel nucleic acids and polypeptides. BACKGROUND OF THE INVENTION . The now routine hybridization cloning and expression cloning techniques clone novel polynucleotides . SUMMARY OF THE INVENTION . The invention relates also to the proteins encoded by such polynucleotides, along with therapeutic, diagnostic and research utilities for these polynucleotides and proteins. These nucleic acid sequences are designated as SEQ ID NO: 1- 1. Sequence Listing. The Mouse Germ-Cell-Specific Leucine-Rich Repeat Protein NALP14: A Member of the NACHT Nucleoside Triphosphatase Family 1. These duplicates appear to be largely composed of sequence regions containing transposable elements and duplicated protein. Official Full-Text Publication: Lineage-Specific Biology Revealed by a Finished Genome Assembly of the Mouse on ResearchGate, the professional network for scientists. Patent application title: NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDS Inventors: Teodozyj Kolasa Meena V. Patel Arturo Perez-Medrano Xueqing Wang Sridhar Peddi. In the nucleic acids provided in the Sequence Listing, A is adenine; C is cytosine; G is guanine; T is thymine; and N is any of the four bases or unlcnown. In the amino acids provided in the Sequence Listing,* corresponds to the stop codon. A polynucleotide comprising a nucleotide sequence having at least 9. SEQ ID NO: 1- 1. 24, or 2. The identifying sequence can be 1. The sequence information can be a segment of any one of SEQ ID NO: 1- 1. SEQ ID NO: 1 - 1. The collection of sequence infonnation or identifiing information of each sequence can be provided on a nucleic acid array. In one embodiment, segments of sequence information are provided on a nucleic acid array to detect the polynucleotide that contains the segment. The array can be designed to detect full- match or mismatch to the polynucleotide that contains the segment. The collection can also be provided in a computer- readable format. Nucleic acid sequences (or their reverse or direct complements) according to the invention have numerous applications in a variety of techniques known to those skilled in the art of molecular biology, such as use as hybridization probes, use as primers for PCR, use in an array, use in computer- readable media, use in sequencing full- length genes, use for chromosome and gene mapping, use in the recombinant production of protein, and use in the generation of anti- sense DNA or RNA, their chemical analogs and the like.
In a particularly preferred embodiment, the nucleic acid sequences of SEQ ID NO: 1- 1. Vollrath et al., Science 2. The polynucleotides of the present invention also include, but are not limited to, a polynucleotide that hybridizes under stringent hybridization conditions to (a) the complement of any one of the nucleotide sequences set forth in SEQ ID NO: 1- 1. SEQ ID NO: 1- 1. 24, or 2. Polypeptides of the invention also include polypeptides with biological activity that are encoded by (a) any of the polynucleotides having a nucleotide sequence set forth in SEQ ID NO: 1- 1. Biologically active variants of any of the polypeptide sequences in the Sequence Listing, and . The polypeptides of the invention may be wholly or partially chemically synthesized but are preferably produced by recombinant means using the genetically engineered cells (e. Polypeptide compositions of the invention may further comprise an acceptable carrier, such as a hydrophilic, e. Preferred embodiments include those in which the protein produced by such processes is a mature form of the protein. These techniques include use as hybridization probes, use as oligomers, or primers, for PCR, use for chiromosome and gene mapping, use in the recombinant production of protein, and use in generation of anti- sense DNA or RNA, their chemical analogs and the like. For example, when the expression of an m. RNA is largely restricted to a particular cell or tissue type, polynucleotides of the invention can be used as hybridization probes to detect the presence of the particular cell or tissue MRNA in a sample using, e. For example, a polypeptide of the invention can be used to generate an antibody that specifically binds the polypeptide. Such antibodies, particularly monoclonal antibodies, are useful for detecting or quantitating the polypeptide in tissue. The polypeptides of the invention can also be used as molecular weight markers, and as a food supplement. Such methods can, for example, be utilized as part of prognostic and diagnostic evaluation of disorders as recited herein and for the identification of subjects exhibiting a predisposition to such conditions. The invention provides a method for detecting the polynucleotides of the invention in a sample, comprising contacting the sample with a compound that binds to and forms a complex with the polynucleotide of interest for a period sufficient to form the complex and under conditions sufficient to form a complex and detecting the complex such that if a complex is detected, the polynucleotide of interest is detected. The invention also provides a method for detecting the polypeptides of the invention in a sample comprising contacting the sample with a compound that binds to and forms a complex with the polypeptide under conditions and for a period sufficient to form the complex and detecting the formation of the complex such that if a complex is formed, the polypeptide is detected. Furthermore, the invention provides methods for evaluating the efficacy of drugs, and monitoring the progress of patients, involved in clinical trials for the treatment of disorders as recited above. Such methods can be utilized, for example, for the identification of compounds that can ameliorate symptoms of disorders as recited herein. Such methods can include, but are not limited to, assays for identifying compounds and other substances that interact with (e. The invention provides a method for identifying a compound that binds to the polypeptides of the invention comprising contacting the compound with a polypeptide of the invention in a cell for a time sufficient to form a polypeptide/compound complex, wherein the complex drives expression of a reporter gene sequence in the cell; and detecting the complex by detecting the reporter gene sequence expression such that if expression of the reporter gene is detected the compound that binds to a polypeptide of the invention is identified. In addition, the invention encompasses methods for treating diseases or disorders as recited herein comprising administering compounds and other substances that modulate the overall activity of the target gene products. Compounds and other substances can affect such modulation either on the level of target gene/protein expression or target protein activity. If no homology is set forth for a sequence, then the polypeptides and polynucleotides of the present invention are useful for a variety of applications, as described herein, including use in arrays for detection. DETAILED DESCRIPTION OF THE INVENTION . According to the invention, the terms . For example, the sequence 5. Complementarity between two single- stranded molecules may be . The degree of complementarity between the nucleic acid strands has significant effects on the efficiency and strength of the hybridization between the nucleic acid strands. PGCs are the source from which GSCs and ES cells are derived. The PGCs, the GSCs and the ES cells are capable of self- renewal. Thus these cells not only populate the germ line and give rise to a plurality of terminally differentiated cells that comprise the adult specialized organs, but are able to regenerate themselves. EMFs include, but are not limited to, promoters, and promoter modulating sequences (inducible elements). One class of EMFs are nucleic acid fragments which induce the expression of an operably linked ORF in response to a specific regulatory factor or physiological event. These phrases also refer to DNA or RNA of genomic or synthetic origin which may be single- stranded or double- stranded and may represent the sense or the antisense strand, to peptide nucleic acid (PNA) or to any DNA- like or RNA- like material. In the sequences herein A is adenine, C is cytosine, T is thyrnine, G is guanine and N is A, C, G, or T (U) or unknown. It is contemplated that where the polynucleotide is RNA, the T (thymine) in the sequences provided herein is substituted with U (uracil). Generally, nucleic acid segments provided by this invention may be assembled from fragments of the genome and short oligonucleotide linkers, or from a series of oligonucleotides, or from individual nucleotides, to provide a synthetic nucleic acid which is capable of being expressed in a recombinant transcriptional unit comprising regulatory elements derived from a microbial or viral operon, or a eukaryotic gene. The fragment is preferably less than about 5. Preferably the probe is from about 6 nucleotides to about 2. Preferably the fragments can be used in polymerase chain reaction (PCR), various hybridization procedures, or microarray procedures to identify or amplify identical or related parts of m. RNA or DNA molecules. A fragment or segment may uniquely identify each polynucleotide sequence of the present invention. Preferably the fragment comprises a sequence substantially similar to any one of SEQ ID NO: 1- 1. They may be labeled by nick translation, Kleniow fill- in reaction, PCR, or other methods well known in the art. Probes of the present invention, their preparation and/or labeling are elaborated in Sambrook, J. The sequence information can be a segment of any one of SEQ ID NO: 1- 1. SEQ ID NO: 1- 1. 24, or 2. Tables 3, 5, 6, and 8. One such segment can be a twenty- mer nucleic acid sequence because the probability that a twenty- mer is fully matched in the human genome is 1 in 3. In the human genome, there are three billion base pairs in one set of chromosomes. Because 4. 20 possible twenty- mers exist, there are 3. Using the same analysis, the probability for a seventeen- mer to be fully matched in the human genome is approximately 1 in 5. When these segments are used in arrays for expression studies, fifteen- mer segments can be used. The probability that the fifteen- mer is fully matched in the expressed sequences is also approximately one in five because expressed sequences comprise less than approximately 5% of the entire genome sequence. The probability that the twenty- five mer would appear in a human genome with a single mismatch is calculated by multiplying the probability for a full match (1. NOVEL COMPOUNDS AS CANNABINOID RECEPTOR LIGANDSAbstract. The present application relates to isothiazolylidene containing compounds. Formula (I). wherein R1, R2, R3, R4, and L are as defined in the. Claims: 1. A compound having formula (I) ##STR0. L is. C. The compound according to claim 1 or a pharmaceutically acceptable salt. R1 is G1, - -NRZ1. RZ5, or. - -ORZ5. The compound according to claim 1 or a pharmaceutically acceptable salt. R2 is alkyl, alkynyl, alkenyl, G1. C(RZb). The compound according to claim 1 or a pharmaceutically acceptable. R3 is hydrogen. or C1- 6 alkyl, and R4 is alkyl, haloalkyl, or G. The compound according to claim 1 or a pharmaceutically acceptable. R3 is hydrogen. C1- 6 alkyl, haloalkyl, or optionally substituted cycloalkyl. R2 is alkyl, alkenyl, alkynyl, G1. C(RZb). The compound according to claim 5 or a pharmaceutically acceptable. R1 is G1. - -NRZ1. RZ5, or - -ORZ5. 7. The compound according to claim 6 or a pharmaceutically acceptable. R4 is alkyl. haloalkyl, or G. The compound according to claim 7 or a pharmaceutically acceptable. R1 is G. sup. 1. 9. The compound according to claim 7 or a pharmaceutically acceptable. L is C. The compound according to claim 7 or a pharmaceutically acceptable. L is S(O). sub. 2. The compound according to claim 7 or a pharmaceutically acceptable. L is C. The compound according to claim 7 or a pharmaceutically acceptable. L is C. The compound according to claim 1 or a pharmaceutically acceptable. R2 and R3. together with the atoms to which they are attached, form a five- , six- . O, S, N, and N(H), each. R2. 1) selected from the group. CN, - -O(R1a). - -C(O)OH, - -C(O)O(alkyl), - -C(O)(R1a), - -N(RZ3)(R3a). N(R3a)C(O)R1a, - -N(R3a)C(O)O(R1a). N(R3a)C(O)N(RZ3)(R3a). N(R3a)S(O)2(R2a). N(R3a)S(O)2. N(RZ3)(R3a), - -SO2(R2a). C(O)N(RZ3)(R3a), - -S(O)2. N(RZ3)(R3a). - -(CR1g. R1h)u- G2, - -(CR1g. R1h)u- -CN. - -(CR1g. R1h)u- -O(R1a), and haloalkyl, two adjacent or. R2. 1) on the same carbon atom, together with said. O, S, and N(H). The compound according to claim 1. R1 is G1. - -NRZ1. RZ5, or - -ORZ5; and. R4 is alkyl, haloalkyl, or. G. sup. 2. 1. 5. The compound according to claim 1. R1 is G. sup. 1. 1. The compound according to claim 1. L is C(O). The compound according to claim 1 having formula (II) ##STR0. G3 is CH2 or N(H); R2. G3, and is oxo, alkyl. CN, - -O(R1a), - -C(O)OH, - -C(O)O(alkyl). C(O)(R1a), - -N(RZ3)(R3a), - -N(R3a)C(O)R1a. N(R3a)C(O)O(R1a), - -N(R3a)C(O)N(RZ3)(R3a). N(R3a)S(O)2(R2a). N(R3a)S(O)2. N(RZ3)(R3a), - -SO2(R2a). C(O)N(RZ3)(R3a), - -S(O)2. N(RZ3)(R3a). - -(CR1g. R1h)u- G2, - -(CR1g. R1h)u- -CN. - -(CR1g. R1h)u- -O(R1a), or haloalkyl; two substituents. R2. 1) on the same carbon atom, together with said carbon atom. O, S, or N(H); r is 0, 1, 2, 3, 4, or 5. R1, L, and R4 are as set forth in claim 1. The compound according to claim 1. R1 is G1. - -NRZ1. RZ5, or - -ORZ5; and. R4 is alkyl, haloalkyl, or. G. sup. 2. 1. 9. The compound according to claim 1. R1 is G. sup. 1. 2. The compound according to claim 1. L is C(O). A compound having Formula (I) according to claim 1, selected from the. N- . A pharmaceutical composition comprising a therapeutically effective. Formula (I) according to claim 1 or a. A method for treating pain in a mammal in need of such treatment. Formula (I) according to claim 1, or a. A method for treating a disorder selected from the group consisting of. Formula. (I) according to claim 1, or a pharmaceutically acceptable salt, solvate. Description. 1. 2/1. Apr. 1. 0, 2. 00. U. S. Provisional Application Ser. Apr. Further this application is a Non- provisional. U. S. Provisional Application Ser. Nov. All of these applications are incorporated herein by. CB1 receptors are highly expressed. These. CB1 receptor- mediated effects, such as euphoria, sedation. CB agonists. Recent studies have. CB2 modulators are analgesic in pre- clinical. CB1 receptor activation. Therefore. compounds that selectively target CB2 receptors are an attractive. Pain is commonly. Nociceptive pain is the. After the injury, the site becomes a. This pain and tenderness are. This pain and tenderness gradually. Even though there may be no. Examples of chronic. Neuropathic pain is not associated. The term neuropathic pain encompasses a. The three most. commonly diagnosed pain types of neuropathic nature are diabetic. HIV pain. In addition, neuropathic. No currently available therapies. The compounds of the present invention are novel CB2. Therefore, compounds. CB2 receptors offer a unique pharmacotherapy for. Such compositions can be administered in. CB) receptor subtype CB2. More. particularly, the methods are useful for treating conditions related to. These objectives should not be deemed to narrow the scope of. Compositions. comprising such compounds and methods for treating conditions and. Definition of a variable on each. Stable compounds are compounds. DEFINITION OF TERMS. Representative examples of alkoxyalkyl include. Representative examples of alkyl include, but are not. Representative. examples of alkynyl include, but are not limited, to acetylenyl. The. bicyclic aryl is naphthyl (including naphth- 1- yl), or a phenyl fused to a. The bicyclic aryl is attached to the parent. The aryl groups can be unsubstituted or substituted. Representative examples of cyanoalkyl include. The. monocyclic cycloalkyl is a carbocyclic ring system containing three to. Examples of. monocyclic ring systems include cyclopropyl, cyclobutyl, cyclopentyl. Examples of. C3- 6 cycloalkyl include cyclopropyl, cyclobutyl, cyclopentyl, and. The bicyclic cycloalkyl is a monocyclic cycloalkyl fused to a. Spirocyclic cycloalkyl is. An. example of a spirocyclic cycloalkyl is spiro. The monocyclic. bicyclic, tricyclic, and spirocyclic cycloalkyls can be unsubstituted or. The monocyclic. cycloalkenyl has four- , five- , six- , seven- or eight carbon atoms and. The four- membered ring systems have one double bond. Representative examples of monocyclic cycloalkenyl groups include. The bicyclic cycloalkenyl is a monocyclic. The monocyclic or. Representative examples of. H- indene, octahydronaphthalenyl and. The monocyclic and bicyclic cycloalkenyl can be. Representative examples of haloalkoxy include. Representative examples of. The monocyclic heterocycle is a. O, N. and S. The three- or four- membered ring contains zero or one double bond. O, N, and S. The. O, N and S. The. six- membered ring contains zero, one or two double bonds and one, two, or. O, N, and S. The. O. N, and S. Representative examples of monocyclic heterocycles include, but. The bicyclic heterocycle is a monocyclic heterocycle fused to. Representative examples. Spirocyclic heterocycle means a monocyclic. One example of. a spiroheterocycle is 5- oxaspiro. Tricyclic heterocycles are. Examples of. tricyclic heterocycles include, but are not limited to. H- 2,5- methanocyclopenta. The monocyclic, bicyclic. The nitrogen. and sulfur heteroatoms in the heterocycle rings may optionally be. The monocyclic heteroaryl is a five- or. The five- membered ring contains two double bonds. The. five membered ring may contain one heteroatom selected from O or S; or. The six- membered ring contains three double bonds and one. Representative examples of monocyclic. The bicyclic heteroaryl consists of a monocyclic heteroaryl. The monocyclic and bicyclic heteroaryl. The nitrogen and sulfur heteroatoms of. Representative examples of. Such values may be used where appropriate with any of the. For example, in certain embodiments, m. In other embodiments, m is 1, 2, or 3. In yet other. embodiments, m is 1 or 2. In other. embodiments, m is 1, 2, or 3. In yet other embodiments, m is 1 or 2. Examples of G1 include, but are not. Examples of G1 include, but are not limited to, aryl (e. Examples of the optional. Ra and Rb are as described. Summary section. Examples of Ra include, but are. C1- 6 alkyl (e. g. Examples of Rb include, but are not limited to. C1- 6 alkyl (e. g. Each. occurrence of Ra, Rb, RZb, and RZ1 are, for example. C1- 6 alkyl (e. g. Examples of RZa include, but are not. C1- 6 alkyl such as, but not. CRc. Rd)q- -CN and. CRc. Rd)q- G1 wherein Rc, Rd, q, G1. Summary. G1, for example, is optionally. Each. occurrence of Rc and Rd, are each independently hydrogen or. C1- 6 alkyl (e. g. In certain. embodiments, q is 1. RZ1, for example, is hydrogen or C1- 3. RZ2b, for example, is - -C(O)O(RZc) wherein. RZc is as described in the Summary. RZa, for example, is. C1- 6 alkyl (e. g. In certain embodiments, RZa is. C1- 6 alkyl such as, but not limited to, methyl. C1- 6 haloalkyl. such as, but not limited to, 2,2,2- trifluoroethyl, 2- fluoroethyl. CRc. Rd)q- G1 wherein q. Rc, Rd, and G1 are as described in the Summary and in. G1, for example, is optionally substituted. In certain. embodiments, each occurrence of Ra, Rc, and Rd, are, for. C1- 6 alkyl (e. g. Rb, at each occurrence is, for example, independently. C1- 6 alkyl (e. g. In certain embodiments, q is 1. RZ1 and RZ2b are, for. C1- 6 alkyl (e. g. In certain embodiments, R3 is. C1- 6 alkyl (e. g. In certain embodiments, R3 is. C1- 6 alkyl (e. g. In certain embodiments, R4 is. C1- 6 alkyl such as, but not limited to, methyl. In certain embodiments. G2 is cyclopropyl or cyclobutyl, each of which is optionally. C1- 3 alkyl (e. g. For example, in certain embodiments, m is 1. In other embodiments, m is 1, 2, or 3. In yet other. embodiments, m is 1 or 2. For example, RZ5 is alkyl (e. G1a, and. G1a is as set forth in the Summary. For example, G1a is. For example. RZ5 is G1a or. CRa. Rb)m- -C(O)N(RZ1)(RZ1) wherein G1a. Ra, Rb, m, and RZ1 are as set forth in the Summary. For. example, each occurrence of Ra and Rb are each independently. RZ1, at each. occurrence, is independently hydrogen or alkyl (e. G1a, for example, is. Non limiting examples of the optional. G1a are alkyl, haloalkyl, and oxo. In yet other embodiments, G1 is. In certain embodiments, R1 is optionally. In. certain embodiments, R1 is pyrrolidinyl, dihydropyranyl. For example, each occurrence of R1a is. C1- 6 alkyl (e. g. L1- A1, wherein L1 and A1 are as disclosed. Summary. For example, L1 is O and A1 is R1a. N(RZ3)(R1a), or - -(CR1g. R1h)u- A2, wherein. Novel nucleic acids and polypeptides. DETAILED DESCRIPTION OF THE INVENTION . According to the invention, the terms “biologically active” or “biological activity” refer to a protein or peptide having structural, regulatory or biochemical functions of a naturally occurring molecule. Likewise “immunologically active” or “immunological activity” refers to the capability of the natural, recombinant or synthetic polypeptide to induce a specific immune response in appropriate animals or cells and to bind with specific antibodies. For example, the sequence 5. Complementarity between two single- stranded molecules may be “partial” such that only certain portion(s) of the nucleic acids bind or it may be “complete” such that total complementarity exists between the single stranded molecules. The degree of complementarity between the nucleic acid strands has significant effects on the efficiency and strength of the hybridization between the nucleic acid strands. The term “primordial germ cells (PGCs)” refers to a small population of cells set aside from other cell lineages particularly from the yolk sac, mesenteries, or gonadal ridges during embryogenesis that have the potential to differentiate into germ cells and other cells. PGCs are the source from which GSCs and ES cells are derived. The PGCs, the GSCs and the ES cells are capable of self- renewal. Thus these cells not only populate the germ line and give rise to a plurality of terminally differentiated cells that comprise the adult specialized organs, but are able to regenerate themselves. EMFs include, but are not limited to, promoters, and promoter modulating sequences (inducible elements). One class of EMFs are nucleic acid fragments which induce the expression of an operably linked ORF in response to a specific regulatory factor or physiological event. These phrases also refer to DNA or RNA of genomic or synthetic origin which may be single- stranded or double- stranded and may represent the sense or the antisense strand, to peptide nucleic acid (PNA) or to any DNA- like or RNA- like material. In the sequences herein A is adenine, C is cytosine, T is thyrnine, G is guanine and N is A, C, G, or T (U) or unknown. It is contemplated that where the polynucleotide is RNA, the T (thymine) in the sequences provided herein is substituted with U (uracil). Generally, nucleic acid segments provided by this invention may be assembled from fragments of the genome and short oligonucleotide linkers, or from a series of oligonucleotides, or from individual nucleotides, to provide a synthetic nucleic acid which is capable of being expressed in a recombinant transcriptional unit comprising regulatory elements derived from a microbial or viral operon, or a eukaryotic gene. The fragment is preferably less than about 5. Preferably the probe is from about 6 nucleotides to about 2. Preferably the fragments can be used in polymerase chain reaction (PCR), various hybridization procedures, or microarray procedures to identify or amplify identical or related parts of m. RNA or DNA molecules. A fragment or segment may uniquely identify each polynucleotide sequence of the present invention. Preferably the fragment comprises a sequence substantially similar to any one of SEQ ID NO: 1- 1. They may be labeled by nick translation, Kleniow fill- in reaction, PCR, or other methods well known in the art. Probes of the present invention, their preparation and/or labeling are elaborated in Sambrook, J. The sequence information can be a segment of any one of SEQ ID NO: 1- 1. SEQ ID NO: 1- 1. 24, or 2. Tables 3, 5, 6, and 8. One such segment can be a twenty- mer nucleic acid sequence because the probability that a twenty- mer is fully matched in the human genome is 1 in 3. In the human genome, there are three billion base pairs in one set of chromosomes. Because 4. 20 possible twenty- mers exist, there are 3. Using the same analysis, the probability for a seventeen- mer to be fully matched in the human genome is approximately 1 in 5. When these segments are used in arrays for expression studies, fifteen- mer segments can be used. The probability that the fifteen- mer is fully matched in the expressed sequences is also approximately one in five because expressed sequences comprise less than approximately 5% of the entire genome sequence. The probability that the twenty- five mer would appear in a human genome with a single mismatch is calculated by multiplying the probability for a full match (1. The probability that an eighteen mer with a single mismatch can be detected in an array for expression studies is approximately one in five. The probability that a twenty- mer with a single mismatch can be detected in a human genome is approximately one in five. For example, a promoter is operably associated or operably linked with a coding sequence if the promoter controls the transcription of the coding sequence. While operably linked nucleic acid sequences can be contiguous and in the same reading frame, certain genetic elements e. A pluripotent cell is restricted in its differentiation capability in comparison to a totipotent cell. A polypeptide “fragment,” “portion,” or “segment” is a stretch of amino acid residues of at least about 5 amino acids, preferably at least about 7 amino acids, more preferably at least about 9 amino acids and most preferably at least about 1. The peptide preferably is not greater than about 2. Preferably the peptide is from about 5 to about 2. To be active, any polypeptide must have sufficient length to display biological and/or immunological activity. The “mature protein portion” means that portion of the protein which does not include a signal or leader sequence. The peptide may have been produced by processing in the cell which removes any leader/signal sequence. The mature protein portion may or may not include the initial methionine residue. The methionine residue may be removed from the protein during processing in the cell. The peptide may be produced synthetically or the protein may have been produced usilng a polynucleotide only encoding for the mature protein coding sequence. Guidance in determining which amino acid residues may be replaced, added or deleted without abolishing activities of interest, may be found by comparing the sequence of the particular polypeptide with that of homologous peptides and minimizing the number of amino acid sequence changes made in regions of high homology (conserved regions) or by replacing amino acids with consensus sequence. Various codon substitutions, such as the silent changes which produce various restriction sites, may be introduced to optimize cloning into a plasmid or viral vector or expression in a particular prokaryotic or eukaryotic system. Mutations in the polynucleotide sequence may be reflected in the polypeptide or domains of other peptides added to the polypeptide to modify the properties of any part of the polypeptide, to change characteristics such as ligand- binding affinities, interchain affinities, or degradation/turnover rate. For example, nonpolar (hydrophobic) amino acids include alanine, leucine, isoleucine, valine, proline, All phenylalanine, tryptophan, and methionine; polar neutral amino acids include glycine, serine, threonine, cysteine, tyrosine, asparagine, and glutamine; positively charged (basic) amino acids include arginine, lysine, and histidine; and negatively charged (acidic) amino acids include aspartic acid and glutamic acid. The variation allowed may be experimentally determined by systematically making insertions, deletions, or substitutions of amino acids in a polypeptide molecule using recombinant DNA techniques and assaying the resulting recombinant variants for activity. Such alterations can, for example, alter one or more of the biological functions or biochemical characteristics of the polypeptides of the invention. For, example, such alterations may change polypeptide characteristics such as ligand- binding affinities, interchain affinities, or degradation/turnover rate. Further, such alterations can be selected so as to generate polypeptides that are better suited for expression, scale up and the like in the host cells chosen for expression. For example, cysteine residues can be deleted or substituted with another amino acid residue in order to eliminate disulfide bridges. In one embodiment, the polylnucleotide or polypeptide is purified such that it constitutes at least 9. In one embodiment, the nucleic acid or polypeptide is found in the presence of (if anything) only a solvent, buffer, ion, or other component normally present in a solution of the same. The terms “isolated” and “purified” do not encompass nucleic acids or polypeptides present in their natural source. As a product, “recombinant microbial” defines a polypeptide or protein essentially free of native endogenous substances and unaccompanied by associated native glycosylation. Polypeptides or proteins expressed in most bacterial cultures, e. E. An expression vehicle can comprise a transcriptional unit comprising an assembly of (1) a genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers, (2) a structural or coding sequence which is transcribed into m. RNA and translated into protein, and (3) appropriate transcription initiation and termination sequences. Structural units intended for use in yeast or eukaryotic expression systems preferably include a leader sequence enabling extracellular secretion of translated protein by a host cell. Alternatively, where recombinant protein is expressed without a leader or transport sequence, it may include an amino termninal metlionine residue. This residue may or may not be subsequently cleaved from the expressed recombinant protein to provide a final product. Recombinant expression systems as defined herein will express heterologous polypeptides or proteins upon induction of the regulatory elements linlked to the DNA segment or synthetic gene to be expressed. Walgreens Pharmacy - 1. NE 8. 5TH ST, Kirkland, WA 9. Patient care services at Healthcare Clinic locations at Walgreens are provided by Take Care Health Services, an independently owned professional corporation whose licensed healthcare professionals are not employed by or agents of Walgreen Co., or its subsidiaries, including Take Care Health Systems, LLC. Patient care services at DR Walk- in Medical Care locations at Duane Reade are provided by Take Care Medical Health New York, P. C., an independently owned professional corporation and provider practice whose licensed healthcare professionals are not employed by or agents of Walgreen Co., or its subsidiaries, including Duane Reade and Take Care Health Systems, LLC. With no fees to sell tickets and live 24/7 phone and web sales, Brown Paper Tickets is the smartest way to sell tickets for your next event! Ticket buyers pay just $0. Walgreens Pharmacy at 12405 NE 85TH ST in Kirkland WA. View Pharmacy Hours, Refill prescriptions online and get directions to Walgreens We do custom vehicle graphics from car graphics to boat graphics and from truck graphics and van graphics to trailer graphics! And if you need side or rear window. Find a local pharmacist nearby Federal Way, WA using the pharmacy map on RxList. The pharmacies listed may include chain pharmacies (CVS Pharmacy, Rite Aid Pharmacy. Sauna/Steam Room 07.13.2013. These amenities provide. Jay's Signature Pizza Crust Recipe. Click here to check out Kroger Digital coupons - you'll find storewide savings on some of your favorite brands. Ok, so what is this LCHF then? This is true LCHF: Basics. The abbreviation stands for Low Carb High Fat and the very simple basics are to minimize the carbs in your. AXS.com brings you inside access to tickets, artist news, and exclusive stories on concerts, tours, sports teams, family events, arts, theater, and festivals.
Calorie Diet Meal Plan With High Protein. A 1,5. 00- calorie, high- protein diet can help you to boost metabolic functions and maintain lean muscle mass. Maintaining a diet that is low in fat and high in protein can be difficult. Create a meal plan that includes a lean source of protein, such as salmon or chicken, in each meal or snack. Couple eating healthy meal. Photo Credit Stockbyte/Stockbyte/Getty Images. A balance of healthy fats, carbohydrates and protein is vital in a 1,5. Diets that cut out a certain food group or macronutrient, such as the Cabbage Soup Diet, will cause nutritional deficiencies, says the American Heart Association. Forks with different food groups. Photo Credit yuelan/i. Stock/Getty Images. Aim for three meals that contain about 4. Portion control is an important aspect of meal preparation. Portion size and serving size are often confused when preparing meals, says the Centers of Disease Control and Prevention. For example, a large bagel can contain two servings of 3. Omelet with fruit. Follow this free 1600 calorie diet to lose weight and keep it off. This easy diet menu is well balanced and absolutely healthy. The Weight Loss Resources Tools. WLR has everything you need to follow a calorie controlled diet. We'll calculate how many calories you need to lose weight and give. Maintaining a diet that is low in fat and high. This 1,600-calorie meal plan is designed by EatingWell's registered dietitians and culinary experts to offer healthy and delicious meals for weight loss. Photo Credit Lilechka. Stock/Getty Images. When planning your meals, be sure to include 4 oz.
A veggie omelet with a serving of fresh fruit is a high- protein breakfast idea. Lunch could be a turkey sandwich with plenty of vegetables and a side of cottage cheese. A healthy dinner option could be a large chicken salad with low- calorie dressing and a side of steamed asparagus. Some high- protein snacks include a handful of almonds, nonfat Greek yogurt, a protein shake or string cheese. Bowls of processed foods. Photo Credit carotur/i. Stock/Getty Images. Balance your meals by including whole, natural foods such as low- fat dairy products, lean meats, whole grains, fruits and vegetables. These foods are high in protein, which will speed up metabolism, build and repair muscle tissue and keep you fuller for longer. Avoid processed foods such as crackers and chips that contain enriched flour, preservatives and chemicals. Woman jogging. Photo Credit Jed Share/Kaoru Share/Blend Images/Getty Images. Combining regular exercise with proper diet can improve your overall body composition by building and maintaining muscle mass. Include both cardiovascular exercise and strength training into your exercise plan. If you experience low energy levels during exercise, then consider adding more calories to your diet to increase performance. Follow this free 1800 calorie diet to lose weight or to maintain it. This easy diet menu is well balanced and absolutely healthy. Calorie Diet Sample Plan. Yes. Losing would also be beneficial to your health and could make you look and feel better. You could lose in weeks with Weight Loss Resources. Our free trial will show you how. You should lose to be within the healthy weight range for your height. Losing would also be beneficial to your health and could make you look and feel better. You could lose in weeks with Weight Loss Resources. Our free trial will show you how. You should lose to be within the healthy weight range for your height. Losing would also be beneficial to your health and could make you look and feel better. You could lose in weeks with Weight Loss Resources. Our free trial will show you how! I signed up for a free trial and bought a 6 month subscription the same day.” Matt (Beer. Matt) has lost 4st 1. Weight Loss Resources. Yes. Losing would put you in the middle of the healthy weight range for your height. Losing would be beneficial to your health and could make you look and feel better. You could lose in weeks with Weight Loss Resources. Our free trial will show you how. You have a BMI of - a BMI of 1. However, you could lose up to and remain within your healthy weight range. Losing could make you look and feel better. You could lose in weeks with Weight Loss Resources. Our free trial will show you how. Losing could make you look and feel better. You could lose in weeks with Weight Loss Resources. Our free trial will show you how. You can learn a lot about healthy eating this way.” Maria (Einstein. MC), Weight Loss Resources' member. No. Calories and fat per serving of each food alongside 1. Easy to use listings with a separate Eating Out section. Food Politics by Marion Nestle » Where did the 2,0. I’m in the midst of working on the copy- edited manuscript of my forthcoming book with Malden Nesheim Why Calories Count: From Science to Politics (University of California Press, March 2. I have on it. Short of metabolic testing (and I read conflicting opinions on that, too), it seems rather difficult to figure out how much I should be eating. A. Your daily values may be higher or lower depending on your calorie needs.”Here’s the history of where that came from: The FDA wanted consumers to be able to compare the amounts of saturated fat and sodium to the maximum amounts recommended for a day’s intake—the Daily Values. But stating ranges on food labels would take up too much space and did not seem particularly helpful. The FDA proposed using a single standard of daily calorie intake—2,3. USDA survey data. The agency requested public comments on this proposal and on alternative figures: 2,0. Despite the observable fact that 2,3. Nutrition educators worried that it would encourage overconsumption, be irrelevant to women who consume fewer calories, and permit overstatement of acceptable levels of “eat less” nutrients such as saturated fat and sodium. Instead, they proposed 2,0. Whether a rounding down of nearly 2. FDA ultimately viewed these arguments as persuasive. It agreed that 2,0. The FDA wanted people to understand that they must adjust calorie intake according to age, sex, activity, and life stage. It addressed the adjustment problem by requiring the percent Daily Value footnote on food labels for diets of 2,0. As to how many calories you personally need, I think they are too difficult for most people to count accurately to bother. |
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